re = /(?<=\bRate: )(?:[5-9]\d{3}|[1-9]\d{4,})\b/
str = ' - Item: Oldman\'s_Romance
Rate: 50
- Item: Grasshopper\'s_Leg
Rate: 8000
- Item: Azure_Jewel
Rate: 9000
- Item: Grasshopper_Doll
Rate: 1500
- Item: Angel\'s_Arrival
Rate: 1000
- Item: Center_Potion
Rate: 700
- Item: Angel\'s_Departure
Rate: 10600
- Item: Left_Potion
Rate: 23471
- Item: Right_Potion
aRate: 6000'
subst = '5000'
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html