$re = '/^(.*?)OldKeyword/m';
$str = 'OldKeyword stuff stuff stuff
stuff stuff stuff OldKeyword stuff stuff stuff';
$subst = "hashtag Comments\n$1NewKeyword";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php