$re = '/(<head\b[^<>]*>)([\s\S]*?)(<\/head>)/i';
$str = '<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8" />
<title>E-Library - Information At Your Fingertips: Printer Friendly</title>
<style>body
{
margin: 5px 50px 40px 50px;
color: #000000;
font-family:Verdana, Arial, Helvetica, sans-serif;
font-size: 90%;
line-height: 20px;
}
</style>
</head>
<BR><BR>
<CENTER>
<H2>SECOND DIVISION</H2>
<H2 style=\'background-color:#cccccc;padding-top:10px;padding-bottom:10px;\'>[ G.R. No. 180416, June 02, 2014 ]</H2>
<H3>ADERITO Z. YUJUICO AND BONIFACIO C. SUMBILLA, PETITIONERS, VS. CEZAR T. QUIAMBAO AND ERIC C. PILAPIL, RESPONDENTS.<BR><BR>D E C I S I O N</H3>
</CENTER>
<p><STRONG>PEREZ, J.:</STRONG></p>
<p><div align="JUSTIFY">This case is a Petition for Review on <i>Certiorari</i><sup style="color: rgb(255, 0, 0);">[1]</sup> from the <i>Order</i><sup style="color: rgb(255, 0, 0);">[2]</sup> dated 4 June 2007 and 5 November 2007 of the Regional Trial Court (RTC), Branch 154, of Pasig City in S.C.A. No. 3047.<br><br>The facts:<br><br><center><i><u>Backgrou
</html>';
$subst = "$1foo$3";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php