$re = '/(?:Filename=)(.*)(\.pdf)(?:&)/m';
$str = 'ID=6913&Filename=C%3A%5CUsers%5CTHanse04%5CAppData%5CRoaming%5CDocumentum%5CViewed%5C181019_ERS_321_102_500857.pdf&Download=65536&DownloadSize=79243& HTTP/1.1" 200 3 "-" "Java/1.8.0_192';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php