$re = '/(?<=\d),(?=[\d,]*-)/m';
$str = '6,7- dihydro-1,1,2,3,3-pentamethyl-4(5h)-indanone
steareth-10, polyacrylamide c1,14 isoparaffin, laureth-7, propylene glycol, hydrolyzed soy protein, aloe barbadensis, 1,2-hexanediol
1,1,2,3,3';
$subst = "-";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php