const regex = /^.+? ?, ?(A[LKSZRAP]|C[AOT]|D[EC]|F[LM]|G[AU]|HI|I[ADL N]|K[SY]|LA|M[ADEHINOPST]|N[CDEHJMVY]|O[HKR]|P[ARW]|RI|S[CD] |T[NX]|UT|V[AIT]|W[AIVY])$/i;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('^.+? ?, ?(A[LKSZRAP]|C[AOT]|D[EC]|F[LM]|G[AU]|HI|I[ADL N]|K[SY]|LA|M[ADEHINOPST]|N[CDEHJMVY]|O[HKR]|P[ARW]|RI|S[CD] |T[NX]|UT|V[AIT]|W[AIVY])$', 'i')
const str = `los angeles, ca`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions