const regex = /pam\.username%([A-Za-z0-9]+)@|\s\(([0-9]+)\)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('pam\\.username%([A-Za-z0-9]+)@|\\s\\(([0-9]+)\\)', 'gm')
const str = `Sep 11 03:02:00 (1568505720.145620) danted[10402]: info: pass(2): tcp/connect -: pam.username%MyUsername@46.111.111.250.48198 123.12.12.112.1080 -> 123.12.12.112.48198 111.123.123.147.443 (319721)
Sep 11 03:02:00 (1568505720.147471) danted[10402]: info: pass(2): tcp/connect -: pam.username%MyUsername@46.111.111.250.37449 123.12.12.112.1080 -> 123.12.12.112.37449 123.123.123.211.443 (312)
Sep 11 03:02:00 (1568505720.148240) danted[10402]: info: pass(2): tcp/connect -: 111.123.123.147.443 123.12.12.112.48198 -> 123.12.12.112.1080 pam.username%MyUsername@46.111.111.250.48198 (723)
Sep 11 03:02:00 (1568505720.154784) danted[10402]: info: pass(2): tcp/connect -: 123.123.123.211.443 123.12.12.112.37449 -> 123.12.12.112.1080 pam.username%MyUsername@46.111.111.250.37449 (8831)`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions