const regex = /^(?:Mrs?|Ms|[DE]r)\.\s*[A-Za-z]/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('^(?:Mrs?|Ms|[DE]r)\\.\\s*[A-Za-z]', 'gm')
const str = `Mr. Abc
Mrs.Abc
Ms. Abc
Dr. Abc
Er. Abc`;
const subst = `.`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions