const regex = /^(?:[^_]*_){3}([^_]+_[^_]+)_(?:[^_]+_){3}([^_]+_[^_]+).*/mg;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('^(?:[^_]*_){3}([^_]+_[^_]+)_(?:[^_]+_){3}([^_]+_[^_]+).*', 'mg')
const str = `a_b_c_d_e_f_g_1_2_3_4_5
_b_c_dd_ee_f_g_1_222_333_4_5
b_c_dd_ee_f_g_1_222_333_4_5
_c_dd_ee_ff_g_1_222_333_444_5
c_dd_ee_ff_g_1_222_333_444_55_66
_dd_ee_ff_gg_1_222_333_444_55_66`;
const subst = `$1_$2`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions