const regex = /center=(\d+(?:\.\d+)?)%2C(-?\d+(?:\.\d+)?)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('center=(\\d+(?:\\.\\d+)?)%2C(-?\\d+(?:\\.\\d+)?)', 'gm')
const str = `<img alt="Map" height="135" src="http://maps.google.com/maps/api/staticmap?scale=2&center=45.504358%2C-73.553712&language=en&zoom=15&markers=scale%3A2%7Cshadow%3Afalse%7Cicon%3Ahttp%3A%2F%2Fyelp-images.s3.amazonaws.com%2Fassets%2Fmap-markers%2Fannotation_64x86.png%7C45.504358%2C-73.553712&client=gme-yelp&sensor=false&size=286x135&signature=nM1FwS0L3z_VgK2ljaRcJf11HxA=" width="286">`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions