$re = '/\(*(\(\d{4}_-_\d{2}_-_\d{2} \d{2}:\d{2}[\s|]*[ap]m\))\)*/m';
$str = 'hhhh ((44_-_44)) ggj ((2022_-_02_-_18 20:00 pm)) ((((2022_-_02_-_18 20:00 pm))) (2022_-_02_-_18 00:00 am)';
$subst = "\1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php