use strict;
my $str = '#\'YOUR_ANSWER
As_samp2 = 36
As_samp3 = 38
#\'END_ANSWER
';
my $regex = qr/#'YOUR_ANSWER.*(?:\R(?!\h*#'END_ANSWER$).*)*\R\h*#'END_ANSWER$/mp;
my $subst = 'space for answer';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html