const regex = /\A(?:^(?!.*\bLecture\b).*\r?\n)*|^\r?\n|^.*\r?\n(?![\s\S]*\bLecture\b)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('\\A(?:^(?!.*\\bLecture\\b).*\\r?\\n)*|^\\r?\\n|^.*\\r?\\n(?![\\s\\S]*\\bLecture\\b)', 'gm')
const str = `My Dashboard
Fnfjfjf. random test
00:50
1:01:56
My Notes
No data found.
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Estimation of Working Capital Lecture 1
Estimation of Working Capital Lecture 2
Estimation of Working Capital Lecture 3
Money Market Lecture 254
Money Market Lecture 255
Money Market Lecture 256
International Trade Lecture 257
International Trade Lecture 258
International Trade Lecture 259
Terms And Conditions
84749473837373
Random text fifjfofifofjfkfkf
`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions