$re = '~(?s)(?:\G(?!\A)|<tags>(?=.*?</tags>))(?:(?!</?tags>).)*?\K\s+~m';
$str = '<tags>This is an example</tags>';
$subst = ",";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php