$re = '/(?:(?:ht|f)tp(?:s?)\:\/\/|~\/|\/)?(?:\w+:\w+@)?((?:(?:[-\w\d{1-3}]+\.)+(?:com|org|net|gov|mil|biz|info|mobi|name|aero|jobs|edu|co\.uk|ac\.uk|it|fr|tv|museum|asia|local|travel|[a-z]{2}))|((\b25[0-5]\b|\b[2][0-4][0-9]\b|\b[0-1]?[0-9]?[0-9]\b)(\.(\b25[0-5]\b|\b[2][0-4][0-9]\b|\b[0-1]?[0-9]?[0-9]\b)){3}))(?::[\d]{1,5})?(?:(?:(?:\/(?:[-\w~!$+|.,=]|%[a-f\d]{2})+)+|\/)+|\?|#)?(?:(?:\?(?:[-\w~!$+|.,*:]|%[a-f\d{2}])+=?(?:[-\w~!$+|.,*:=]|%[a-f\d]{2})*)(?:&(?:[-\w~!$+|.,*:]|%[a-f\d{2}])+=?(?:[-\w~!$+|.,*:=]|%[a-f\d]{2})*)*)*(?:#(?:[-\w~!$ |\/.,*:;=]|%[a-f\d]{2})*)?/i';
$str = 'Hey there StackOverflow.com, how\'s stuff.co going? This.xyz is not valid.';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php