$re = '/(?i)(?<!\S)[tdi]\S{5,}/m';
$str = 'i.e txxxxx.domain.local, dxxxxx.domain.local but at the same time it should not match with xtxxxx.domain.local or xdxxxx.domain.local';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php