const regex = /(?<![,\.]\d*?)(?<=\d)(?=(?:\d{3})+(?!,)\b)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?<![,\\.]\\d*?)(?<=\\d)(?=(?:\\d{3})+(?!,)\\b)', 'gm')
const str = `123
.123456
12.12345
123.12345
1234.1234
7777777
111111.1
65432.123456 65665.66 5544433,777665 4456677
123456789
12345.
12312312312312345.123456789
123,456
12345555666,489
12,345,678.12`;
const subst = `,`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions