use strict;
my $str = '1. Br J Biomed Sci. 2015;72(3):93-101.
Effects of propofol and isoflurane on haemodynamics and the inflammatory response
in cardiopulmonary bypass surgery.
Sayed S, Idriss NK, Sayyedf HG, Ashry AA, Rafatt DM, Mohamed AO, Blann AD.
Cardiopulmonary bypass (CPB) causes reperfusion injury that when most severe is
clinically manifested as a systemic inflammatory response syndrome. The
anaesthetic propofol may have anti-inflammatory properties that may reduce such a
response. We hypothesised differing effects of propofol and isoflurane on
inflammatory markers in patients having CBR Forty patients undergoing elective
CPB were randomised to receive either propofol or isoflurane for maintenance of
anaesthesia. CRP, IL-6, IL-8, HIF-1α (ELISA), CD11 and CD18 expression (flow
cytometry), and haemoxygenase (HO-1) promoter polymorphisms (PCR/electrophoresis)
were measured before anaesthetic induction, 4 hours post-CPB, and 24 hours later.
There were no differences in the 4 hours changes in CRP, IL-6, IL-8 or CD18
between the two groups, but those in the propofol group had higher HIF-1α (P =
0.016) and lower CD11 expression (P = 0.026). After 24 hours, compared to the
isoflurane group, the propofol group had significantly lower levels of CRP (P <
0.001), IL-6 (P < 0.001) and IL-8 (P < 0.001), with higher levels CD11 (P =
0.009) and CD18 (P = 0.002) expression. After 24 hours, patients on propofol had
increased expression of shorter HO-1 GT(n) repeats than patients on isoflurane (P
= 0.001). Use of propofol in CPB is associated with a less adverse inflammatory
profile than is isofluorane, and an increased up-regulation of HO-1. This
supports the hypothesis that propofol has anti-inflammatory activity.
PMID: 26510263 [PubMed - indexed for MEDLINE]
11. Br J Biomed Sci. 2015;72(3):93-101.
Effects of propofol and isoflurane on haemodynamics and the inflammatory response
in cardiopulmonary bypass surgery.
Sayed S, Idriss NK, Sayyedf HG, Ashry AA, Rafatt DM, Mohamed AO, Blann AD.
Cardiopulmonary bypass (CPB) causes reperfusion injury that when most severe is
clinically manifested as a systemic inflammatory response syndrome. The
anaesthetic propofol may have anti-inflammatory properties that may reduce such a
response. We hypothesised differing effects of propofol and isoflurane on
inflammatory markers in patients having CBR Forty patients undergoing elective
CPB were randomised to receive either propofol or isoflurane for maintenance of
anaesthesia. CRP, IL-6, IL-8, HIF-1α (ELISA), CD11 and CD18 expression (flow
cytometry), and haemoxygenase (HO-1) promoter polymorphisms (PCR/electrophoresis)
were measured before anaesthetic induction, 4 hours post-CPB, and 24 hours later.
There were no differences in the 4 hours changes in CRP, IL-6, IL-8 or CD18
between the two groups, but those in the propofol group had higher HIF-1α (P =
0.016) and lower CD11 expression (P = 0.026). After 24 hours, compared to the
isoflurane group, the propofol group had significantly lower levels of CRP (P <
0.001), IL-6 (P < 0.001) and IL-8 (P < 0.001), with higher levels CD11 (P =
0.009) and CD18 (P = 0.002) expression. After 24 hours, patients on propofol had
increased expression of shorter HO-1 GT(n) repeats than patients on isoflurane (P
= 0.001). Use of propofol in CPB is associated with a less adverse inflammatory
profile than is isofluorane, and an increased up-regulation of HO-1. This
supports the hypothesis that propofol has anti-inflammatory activity.
PMID: 26510263 [PubMed - indexed for MEDLINE]';
my $regex = qr/(?m)^\s*\d+\..*\R{2} # Get to the title
(?<title>[^\n]*(?:\n(?!\n)[^\n]*)*) # Get title
\R{2} # Get to the authors
[^\n]*(?:\n(?!\R)[^\R]*)* # Consume authors
(?<abstract>[^\[]*(?:\[(?!PubMed[ ]-[ ]indexed[ ]for[ ]MEDLINE\])[^\[]*)*) # Grab abstract/xp;
if ( $str =~ /$regex/g ) {
print "Whole match is ${^MATCH} and its start/end positions can be obtained via \$-[0] and \$+[0]\n";
# print "Capture Group 1 is $1 and its start/end positions can be obtained via \$-[1] and \$+[1]\n";
# print "Capture Group 2 is $2 ... and so on\n";
}
# ${^POSTMATCH} and ${^PREMATCH} are also available with the use of '/p'
# Named capture groups can be called via $+{name}
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html