use strict;
my $str = 'Debug: testing message with no restart-required.endmsg.Warn:garbagestuff.Debug: another message.endmsg.Warn:moregarbage.Debug: this testing message has restart-required.endmsg.Error:server 404 not found.Critical restart-required. Debug: blah blah restart-required.endmsg.';
my $regex = qr/(?:Debug:\s(.+?(?=endmsg)))/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html