$re = '/(?<=\.\s+)(#[a-zA-Z]+ *)+(?! *[^\s])/m';
$str = '#abc #def This is a test paragraph. #ads I only want to remove the hashtags after the full stop at the end and keep the hashtag at the center. These hashtags should be removed. #ads #ime #abc
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php