$re = '/<select(?:(?!<\/select)[\n\s\S])*data-level="2"[\n\s\S]*?<\/select>/mU';
$str = '<div class="lsd-search-filter lsd-col-10">
<label for="lsd_search_10574_listdom-location">Regions</label>
<div class="lsd-hierarchical-dropdowns" id="lsd_search_10574_listdom-location_wrapper" data-for="listdom-location" data-id="lsd_search_10574_listdom-location" data-max-levels="2" data-name="sf-listdom-location" data-hide-empty="0">
<select class="listdom-location" name="sf-listdom-location" id="lsd_search_10574_listdom-location_1" placeholder="Select Region" data-level="1">
<option value="">Select Region</option>
<option class="lsd-option lsd-parent-0" value="289">Region 1</option>
<option class="lsd-option lsd-parent-0" value="391">Region 2</option>
<option class="lsd-option lsd-parent-0" value="290">Region 3</option>
</select>
<select class="listdom-location" name="" id="lsd_search_10574_listdom-location_2" placeholder="Select Region" data-level="2">
<option value="">Select Region</option>
<option class="lsd-option lsd-parent-289" value="291">Area 1</option>
<option class="lsd-option lsd-parent-289" value="292">Area 2</option>
</select>
</div>
</div>';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php