use strict;
my $str = '123
.123456
12.12345
123.12345
1234.1234
7777777
111111.1 5555555555555555
65432.123456
123456789
12345.
12312312312312345.123456789
123,456
1234,456789
12,345,678.12';
my $regex = qr/(.*,.*|\..*)(*SKIP)(*F)|\B(?=(\d{3})+\b)/p;
my $subst = ',';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html