$re = '/(.*,.*|\..*)(*SKIP)(*F)|\B(?=(\d{3})+\b)/';
$str = '123
.123456
12.12345
123.12345
1234.1234
7777777
111111.1 5555555555555555
65432.123456
123456789
12345.
12312312312312345.123456789
123,456
1234,456789
12,345,678.12';
$subst = ",";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php