const regex = /(?m)^(\d{2}:\d{2}:\d{2}\.\d+) +--> +(\d{2}:\d{2}:\d{2}\.\d+).*[\r\n]+\s*(?s)((?:(?!\r?\n\r?\n).)*)/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?m)^(\\d{2}:\\d{2}:\\d{2}\\.\\d+) +--> +(\\d{2}:\\d{2}:\\d{2}\\.\\d+).*[\\r\\n]+\\s*(?s)((?:(?!\\r?\\n\\r?\\n).)*)', 'g')
const str = `00:00:02.736 --> 00:00:06.072 line:79.33% position:10.00% align:start
AND YOUR GRACE?
00:00:06.072 --> 00:00:08.875 line:74.00% position:10.00% align:start
WHAT WILL YOU DO
ABOUT THAT?`;
const subst = `|`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions