$re = '/^.{21,}$(*SKIP)(*FAIL)|bla/m';
$str = '1 testbtblal balbl al2845 tetete gsgsgs tetet
2 testblablablablal gsgsg gsgs gsgsg gsg
3 blabltetst alets jff <-----
4 125testblabal14test ablets blbla
5 test2584blaalj
contains "bla" text
7 4rblatesbaltest845 testblabla test
8 blabalbal878testbaltesbla blabla test
9 2584blaal jstba lest <------
10 blablatest5 45blabla ffftest
';
$subst = "SOME_NEW_STRING";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php