$re = '/^(\"(?:\"[^\"]*\",){3})\"[^\"]*\"|\"[^\"]*\"(\")$/m';
$str = '""00001","Open","2020-10-23 12:45","2022-10-20 15:48","Error not found","Alex Smith","NO ERROR","ErrorApp","FOB","CNSHA","GB","Plane","MODEL","2020-10-24 00:00","New","1","","2022-10-20 15:48""
';
$subst = "$1\"\"$2";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php