const regex = /.*(?: DE: (.*))(?: ID: (.*)){0,1}(?: MOTIF: (.*))(?: REF: (.*)){0,1}/mg;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('.*(?: DE: (.*))(?: ID: (.*)){0,1}(?: MOTIF: (.*))(?: REF: (.*)){0,1}', 'mg')
const str = `PRELEVEMENT EUROPEEN 2001427553 DE: MUTUELLE DE L'INDUSTRIE DU PETROLE ID: FR69MIP108863 MOTIF: Prelevement 42CXK 024 de MIP du 01/
VIR RECU 0485970259S DE: CPAM VAR MOTIF: 180930001235180930001235 REF: 18093000123`;
const subst = `Tiers:\t$1 \rid:\t$2 \rmotif:\t$3\r\r`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions