$re = '/_+\d+_*/m';
$str = '"F1_6346346346_TrainTest_53453465.rds", "F1_64575687357_FunctionTest_747434534.rds", "F3F4_546345647678_TrainTest_453463654.rds" ';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php