const regex = /(http(?:s)?:\/\/)((?:(?:\w+)\.?)+\/)(vtvnpvr\S{0,10}\/sdash\/)(.*)(CUP|TDT)(\S{1,3})(\/\S{4,100})((\?)|(&)device)=(\S{1,5})_(\S{1,5})_(\S{1,100})/;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(http(?:s)?:\\\/\\\/)((?:(?:\\w+)\\.?)+\\\/)(vtvnpvr\\S{0,10}\\\/sdash\\\/)(.*)(CUP|TDT)(\\S{1,3})(\\\/\\S{4,100})((\\?)|(&)device)=(\\S{1,5})_(\\S{1,5})_(\\S{1,100})', '')
const str = `http://vfccastcdn.gb.vodafone.es/vtvnpvr2/sdash/LIVE%24TDT001/2.mpd/Manifest?start=2018-11-20T16:55:00Z&end=2018-11-20T19:30:00Z&device=DASH_VTV_ENC_NPVR
http://vfccastcdn.gb.vodafone.es/vtvnpvr/shss/LIVE%24CUP156/2.ism/Manifest?start=2018-11-20T16:55:00Z&end=2018-11-20T19:30:00Z&device=HSS_OTT_ENC_NPVR
http://vfvtvcdn.gb.vodafone.es/shss/LIVE\$CUP156/2.ism/Manifest?start=2018-02-20T16:00:00Z&end=2018-02-20T17:00:00Z&device=HSS_VTV_AVC_ENC_RB_HD
`;
const subst = `$1vfott2cdn.gb.vodafone.es/$3$4CUP$6$7$8=$11_XDSL_$13`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions