$re = '/(?:\G(?!\A)|^(?!.*\.join\.))(.*?)PD_/m';
$str = 'it.mycompany.db.beans.str1.PD_T_PD_CLASS
it.mycompany.db.beans.join.PD_T_CLASS
it.mycompany.db.beans.str2.PD_T_CLASS_1
it.mycompany.db.beans.join.PD_T_CLASS_1
PD_T_CLASS myVar = new PD_T_CLASS();
myVar.setPD_T_CLASS(something);';
$subst = "$1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php