const regex = /(?i)^(?!((<\/|<)(h[1-6]|ul|li|script|blockquote)(\s.+)*>))(.+)(?!(<(\/\3)>))$/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?i)^(?!((<\\\/|<)(h[1-6]|ul|li|script|blockquote)(\\s.+)*>))(.+)(?!(<(\\\/\\3)>))$', 'gm')
const str = `<h2>Lorem ipsum dolor sit amet, consectetur adipiscing elit</h2>
Vivamus vel tempor turpis, <strong>non rutrum quam</strong>. Suspendisse ac rhoncus felis, eget porta lectus.
Nam vulputate sapien risus, vel vehicula mi volutpat sed.
<ul>
<li>Sed feugiat nibh at nisl eleifend scelerisque.</li>
<li>Aliquam non maximus ipsum. Aliquam erat volutpat.</li>
</ul>
<h3>Praesent eget diam sit amet leo vehicula sagittis at quis tortor</h3>
Nunc nec sem ac nunc tincidunt aliquam ut nec dolor. Nulla facilisi.
<img alt="xxxx" src="xxx.png" class="xxxxx"/>
<caption><i>ccccc</i></caption>
<img alt="xxxx" src="xxx.png" class="xxxxx"/>
<i>ccccc</i>
<strong>Nunc nec sem ac nunc tincidunt aliquam ut nec dolor. Nulla facilisi.</strong>
Vivamus vel tempor turpis, <strong>non rutrum quam</strong>. Suspendisse ac rhoncus felis, eget porta lectus.
Nunc nec
Nunc nec
Nunc nec
<blockquote class="twitter-tweet" data-lang="en"><p lang="en" dir="ltr">Vivamus vel tempor turpis <a href=""></a></p>— xxxxx (@xxxxxx) <a href="https://twitter.com/xxxx/status/x?ref_src=x">February 15, 2019</a></blockquote>
<script async src="" charset="utf-8"></script>`;
const subst = `<p>$5</p>`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions