$re = '/(?i)^(?!((<\/|<)(h[1-6]|ul|li|script|blockquote)(\s.+)*>))(.+)(?!(<(\/\3)>))$/m';
$str = '<h2>Lorem ipsum dolor sit amet, consectetur adipiscing elit</h2>
Vivamus vel tempor turpis, <strong>non rutrum quam</strong>. Suspendisse ac rhoncus felis, eget porta lectus.
Nam vulputate sapien risus, vel vehicula mi volutpat sed.
<ul>
<li>Sed feugiat nibh at nisl eleifend scelerisque.</li>
<li>Aliquam non maximus ipsum. Aliquam erat volutpat.</li>
</ul>
<h3>Praesent eget diam sit amet leo vehicula sagittis at quis tortor</h3>
Nunc nec sem ac nunc tincidunt aliquam ut nec dolor. Nulla facilisi.
<img alt="xxxx" src="xxx.png" class="xxxxx"/>
<caption><i>ccccc</i></caption>
<img alt="xxxx" src="xxx.png" class="xxxxx"/>
<i>ccccc</i>
<strong>Nunc nec sem ac nunc tincidunt aliquam ut nec dolor. Nulla facilisi.</strong>
Vivamus vel tempor turpis, <strong>non rutrum quam</strong>. Suspendisse ac rhoncus felis, eget porta lectus.
Nunc nec
Nunc nec
Nunc nec
<blockquote class="twitter-tweet" data-lang="en"><p lang="en" dir="ltr">Vivamus vel tempor turpis <a href=""></a></p>— xxxxx (@xxxxxx) <a href="https://twitter.com/xxxx/status/x?ref_src=x">February 15, 2019</a></blockquote>
<script async src="" charset="utf-8"></script>';
$subst = "<p>$5</p>";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php