$re = '/\b(?!(?:cookieToKeep1|cookieToKeep2)=)([^;=]+=[^;]*(?:; *|$))/m';
$str = 'someCookie=someValue; anotherCookie=yada61; cookieToKeep1=myValue; cookieToKeep2=myValue2; lastCookie=yada1';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php