re = /(\*{3}.*?)(?:\s*\.{3}DONE=>.*)?(\*{3})$/m
str = '*** HEDAL - 2021 COMPLETE - MF - 03-01-2021...DONE=> AWR 02-2021, BUI 02-2021, PQL 02-2021, NCC 02-2021, ***
*** HEDAL - 2021 COMPLETE - MF - 03-01-2021...DONE=> NCC 03-2021, ***
*** HEDAL - NCC? - MF - 03-01-2021 ***
*** HEDAL - CSP? - MF - 03-02-2021 ...DONE=> PPSC 08-2020, ***
*** HEDAL - WELL CHALI? LSPC? CSP? - MF - 03-02-2021 ***
*** HEDAL - AWR? PHQ? NCC? - MF - 03-05-2021 ...DONE=> BUI 09-2020, ***
*** HEDAL - 2021 COMPLETE - MF - 03-05-2021...DONE=> NWC 02-2021, BUI 02-2021, PQL 02-2021, NCC 02-2021, ***
*** HEDAL - NWC? PQL? NCC? - MF - 03-05-2021 ...DONE=> BUI 12-2020, ***
*** HEDAL - CHALI? NCC? - MF - 03-06-2021 ***
*** HEDAL - CHL? - MF - 03-06-2021 ...DONE=> NWC 02-2021, BUI 02-2021, PQL 02-2021, NCC 02-2021, ***
*** HEDAL - 2021 COMPLETE - MF - 03-08-2021...DONE=> CHALI 01-2021, NCC 01-2021, ***
*** HEDAL - 2021 COMPLETE - MF - 03-02-2021...DONE=> NWC 03-2021, CHL 03-2021, BUI 03-2021, PQL 03-2021, TOBA 03-2021, ***
*** HEDAL - WELL CHILD VISIT? WCC? - MF - 03-06-2021 ***
*** HEDAL -ExAMING? - AZ - 03-01-2021 ...DONE=> AAC 03-2021, LAL 03-2021, MICA 03-2021, BUI 03-2021, TOBA 03-2021, ***'
subst = '$1 $2'
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html