$re = '/\b\d+(?:\.\d+)?\b(*SKIP)(*F)|\d/m';
$str = 'my text contains of the 33109 following values RT3123SO55 and also with certain numbers godwil_5708 and 323stwe and 8y9yc2 456453';
$subst = "*";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php