$re = '/^(?:(?!<p class="test_formal">).)*<span class="test_formal2">.*$/m';
$str = '<p class="test_formal">
<span class="test_formal2">
<p class="test_formal"><span class="test_formal2">
blah <p class="test_formal"><span class="test_formal2"> blah blah
<span class="test_formal2"><p class="test_formal">
blah blah <span class="test_formal2"><p class="test_formal"> blah blah
--------Toto-----
THIS SHOULD NOT BE SELECTED <p class="test_formal"><em>Bla Bla</em></p>
because don\'t have `<span class="test_formal2">`
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php