const regex = /\s*\[\s*\[\s*\[\s*([+-]?\d+(\.\d*)?([EeDd][+-]?\d+)?)\s*,\s*([+-]?\d+(\.\d*)?([EeDd][+-]?\d+)?)\s*\]\s*,\s*\[\s*([+-]?\d+(\.\d*)?([EeDd][+-]?\d+)?)\s*,\s*([+-]?\d+(\.\d*)?([EeDd][+-]?\d+)?)\s*\]\s*,\s*\[\s*([+-]?\d+(\.\d*)?([EeDd][+-]?\d+)?)\s*,\s*([+-]?\d+(\.\d*)?([EeDd][+-]?\d+)?)\s*\]\s*\]\s*\]\s*/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('\\s*\\[\\s*\\[\\s*\\[\\s*([+-]?\\d+(\\.\\d*)?([EeDd][+-]?\\d+)?)\\s*,\\s*([+-]?\\d+(\\.\\d*)?([EeDd][+-]?\\d+)?)\\s*\\]\\s*,\\s*\\[\\s*([+-]?\\d+(\\.\\d*)?([EeDd][+-]?\\d+)?)\\s*,\\s*([+-]?\\d+(\\.\\d*)?([EeDd][+-]?\\d+)?)\\s*\\]\\s*,\\s*\\[\\s*([+-]?\\d+(\\.\\d*)?([EeDd][+-]?\\d+)?)\\s*,\\s*([+-]?\\d+(\\.\\d*)?([EeDd][+-]?\\d+)?)\\s*\\]\\s*\\]\\s*\\]\\s*', 'gm')
const str = `[[[5,3],[2,8],[6,-3]]]
[ [ [ 5.23 , 3.42 ] , [ 2. , 8.17 ] , [ 6 , -3 ] ] ]
[[
[ 5, 3],
[ 2, 8.43],
[ -6.18,-3]
]]
[
[
[
5,
3.141592653
],
[
2.718281828,
8
],
[ 0.618,
-35.16e-17
]
]
]
`;
const subst = `{"\1,\4","\7,\10","\13,\16"}\n`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions