$re = '/^(?!\D*(?:python|php))\D*(\d+)\s?([^\W\d_]+)\s?(\d{2}\s?\d{3})\s?(\w+)/m';
$str = '45 python 00222 sometext
python white 45 regex 00 222 somewhere
php noise 45 python 65000 sm
otherword 45 python 50000 sm
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php