const regex = /,?[^u][^k]:\d+,\d+,\w,\w+,\w+/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp(',?[^u][^k]:\\d+,\\d+,\\w,\\w+,\\w+', 'g')
const str = `ro:2581,1309531682152,A,Place,Page,me:2642,1310989368864,A,Place,Page,uk:2556,1309267095061,A,Place,Page,me:2642,1310989380238,D,Place,Page,me:2642,1334659643627,D,Place,Page,ro:3562,1378721526696,A,Place,Page,uk:1319,1309337246675,D,Place,Page,ro:2581,1379500694666,D,Place,Page,uk:1319,1309337246675,A,Place,Page`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions