use strict;
my $str = 'ro:2581,1309531682152,A,Place,Page,me:2642,1310989368864,A,Place,Page,uk:2556,1309267095061,A,Place,Page,me:2642,1310989380238,D,Place,Page,me:2642,1334659643627,D,Place,Page,ro:3562,1378721526696,A,Place,Page,uk:1319,1309337246675,D,Place,Page,ro:2581,1379500694666,D,Place,Page,uk:1319,1309337246675,A,Place,Page';
my $regex = qr/,?[^u][^k]:\d+,\d+,\w,\w+,\w+/p;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html