use strict;
my $str = '0:00:22.540,0:00:25.440
Hello this is a test';
my $regex = qr/(?<=\d),(?=\d)/p;
my $subst = ' -> ';
my $result = $str =~ s/$regex/$subst/r;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html