use strict;
my $str = 'http://localhost/myweb/login/resend_password?destination=http://localhost%2Fmyweb%2Fsearch%3Fs%3Dislamic_sources%26q%3D%25D8%25B3%25D9%2584%25D8%25A7%25D9%2585';
my $regex = qr/(destination=)[^$|&]+/p;
my $subst = '$1newval';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html