const regex = /^.*(From:|Sent:|Sent\s+From|To:|Subj|Dear\s+(Sir|Madam)|http).*$/gmi;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('^.*(From:|Sent:|Sent\\s+From|To:|Subj|Dear\\s+(Sir|Madam)|http).*$', 'gmi')
const str = ` From: <Name>
Sent: <Datetime>
To: <Name>
Subj Dear Sir/Madam
Hi Vaibhav,
Hope you are doing well.
http://developer.android.com/sdk/index.html
Sent from my Windows 10 phone`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions