re = /^.*(From:|Sent:|Sent\s+From|To:|Subj|Dear\s+(Sir|Madam)|http).*$/mi
str = ' From: <Name>
Sent: <Datetime>
To: <Name>
Subj Dear Sir/Madam
Hi Vaibhav,
Hope you are doing well.
http://developer.android.com/sdk/index.html
Sent from my Windows 10 phone'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html