const regex = new RegExp('(?:(:61:[0-9]{1,6}[0-9]{4}C[0-9]+,[0-9]{0,2})(NMSC.+)(\\r?\\n:86:RGT FACT)|\\G(?!^))[ .](\\d{5})', 'gm')
const str = `:61:2204210421C1339,57NMSCTOPF2510474511//GBBK031SCT TOPF2510474511
:86:RGT FACT 17133 TANQ BROERS SA/RGT39370 TANQ BROERS SA48 AVENUE D'ABCDE
:61:2204270427C4808,37NMSCTOPF2520477320//GBJ6009SCT TOPF2520477320
:86:RGT FACT 17274.17442.17546 TANQ BROERS SA/RGT39370 TANQ BROERS SA48 AVENUE D'ABCDE
:61:2203290329C5518,16NMSCTOPF2485471711//GBCJ001SCT TOPF2485471711
:86:RGT FACT.16794 16918 17079 TANQ BROERS SA/RGT39370 TANQ BROERS SA48 AVENUE D'ABCDE`;
const subst = `$1$2$3INV$4`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions