$re = '/(^|\s)(?!-123(\s|$))-?[0-9.]+(?=\s|$)/m';
$str = '102.3 42.89 98 -812.7 -1234 374 5 -123 8 -123 13 -123 21';
$subst = "\g<1>456";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php