$re = '/^\S+\h+(\S+)\R\K(?:\S+\h+\1(?:\R|\Z))+/m';
$str = 'lineA 12345
lineB 12345
lineC 12345
lineD 788878
lineE 110881
lineF 110881
lineG 110881
lineH 287778
lineJ 251287
lineK 242424
lineL 242424
lineM 242424';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php