re = /^\S+\h+(\S+)\R\K(?:\S+\h+\1(?:\R|\Z))+/m
str = 'lineA 12345
lineB 12345
lineC 12345
lineD 788878
lineE 110881
lineF 110881
lineG 110881
lineH 287778
lineJ 251287
lineK 242424
lineL 242424
lineM 242424'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html