$re = '/(?<=\b|_)you(?=\b|_)/m';
$str = '_you_don\'t_ think_you_don\'t_* you_don\'t__ you_don\'t_know_your_youth';
$subst = "we";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php