$re = '/^\s*\{\/\*DELETE}(\s*(?:\r?\n(?!\s*\{(?:\/\*DELETE|DELETE\*\/)}).*)*)\r?\n\s*\{DELETE\*\/}\s*$/m';
$str = 'Keep1
{/*DELETE}
Delete1a
{/*DELETE}
Delete2
{DELETE*/}
Delete1b
{DELETE*/}
Keep2
{/*DELETE}
Delete3
{DELETE*/}
Keep3';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php